Studies originally conducted by Nakashima et al. in the mid 1990’s suggested a role for EFAs in pyresis and the regulation of body temperature [52]. This led to further work supporting the anti-inflammatory effect of the 11,12-EET regioisomer and demonstration of its ability to inhibit the activation of the NFκB pathway [53]. Some subsequent workers have shown clear evidence of EFAs influencing nuclear translocation NFκB [21].
