Chunk #16 — Online Methods — chromVAR algorithm — Bias corrected deviations and z-scores

Source: chromVAR: inferring transcription-factor-associated accessibility from single-cell epigenomic data.
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The expected number of fragments mapping to every peak containing motif k in cell i is then given by M * ET, and the raw accessibility deviation Y by: Y=M∗XT-M∗ETM∗ET