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Chunk #11 — Methods — Self-Report and Behavioral Measures

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Divergent responses of the amygdala and ventral striatum predict stress-related problem drinking in young adults: possible differential markers of affective and impulsive pathways of risk for alcohol use disorder.
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the Childhood Trauma Questionnaire (CTQ)41 and used CTQ Total scores as a covariate in all regression analyses. Current levels of anxiety and dysphoria were assessed using the Mood and Anxiety Symptom Questionnaire (MASQ). The MASQ provides four subscales – general distress depression (GDD) and anxiety (GAD), reflecting non-specific shared depressive and anxious symptomatology, as well as anxious arousal (AA) and anhedonia (AD), which reflect symptoms specific to anxiety and depression, respectively.42 Notably, two thirds of the items included in the AD scale are positively phrased (e.g., “I felt cheerful”, “I felt optimistic” etc). Thus we conceptualize the AD scale as tapping into positive emotion and hedonic processing more generally, rather than anhedonia specifically. Finally, behavioral impulsivity was measured using a computerized monetary delay discounting task (Supplementary Methods).12