Chunk #47 — METHODS — PrediXcan-S methods.

Source

Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program.

Embedded

yes

Text

To perform transcriptome-wide association analysis, PrediXcan-S (also known as MetaXcan)41 was used to impute gene expression based on the GWAS summary statistics (meta-analysis of tranche 1 and 2 EAs) of PCL-Total with the reference gene expression data of 48 tissues from GTEx Release V7. Gene-expression association with PTSD PCL-Total was performed for each tissue (13 of which are brain tissues) individually.