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Chunk #0 — Introduction

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Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies.
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Alcohol consumption guidelines vary substantially across the globe.1, 2 In the USA, for example, an upper limit of 196 g per week (about 11 standard UK glasses of wine or pints of beer per week) is recommended for men, and an upper limit of 98 g per week is recommended for women.1 Similar recommendations apply in Canada and Sweden.2 By contrast, guidelines in Italy, Portugal, and Spain recommend low-risk limits almost 50% higher than these.1, 2 At the other extreme, UK guidelines recommend low-risk limits for men almost half that recommended by US guidelines.1, 2