We conducted genome-wide association analyses, for DSM-IV based ASPD, using the entire GWAS study sample (N cases=370, N controls=5850), as well as in the sample including only males (N cases=339, N controls=3345). The number of the female cases was too small (N=31) to perform a separate analysis. The Manhattan plots for the genome-wide analyses are presented in Figure 2, illustrating the results of the analyses for the whole sample, and the sample including only males, respectively. Supplementary Tables 1a and 1b display the most significant 50 variants associated with antisocial personality disorder in the combined sample, and in males, respectively. None of the associations achieved genome-wide significance (P<5.0 × 10−8). However, in the quantile-quantile (Q–Q) plots for the observed versus expected results (−10 log(P-value)), for both analyses, several data points were observed above the lift of line indicating more significant associations than expected by chance (Supplementary Figures 1a and b).
