For neuroticism, seven independent SNPs in five genes showed suggestive significance. Four SNPs showed suggestive association with extraversion, with two in the same locus. Five SNPs were identified for depression symptoms: three located in genes (RAVER1, WWOX, FAM190A) and two near genes. Three SNPs passed suggestive significance for anxiety symptoms: two located in FHIT and one nearby ZNF438. For psychological distress symptoms, four SNPs showed suggestive association: three were near TNFRSF21 and the other located in NOS1. Nominally significant associations with the other correlated variables for each of the suggestively associated SNPs are reported in Table 2. Pleiotropic effects with other variables were indicated for all the top SNPs except those for extraversion. The extraversion polygenic score significantly predicted psychological distress variation (r=0.03, P=0.04), and the neuroticism polygenic score significantly predicted depression symptoms (r=0.03, P=0.03).
