Relapse is a common clinical problem in individuals with substance dependence. Previous studies have implicated a multifactorial process underlying relapse; however, the contribution of specific neural substrates had yet to be examined. We 63 looked at whether results from functional imaging shortly after drug cessation could predict relapse in stimulant dependent individuals. The goals were to evaluate the neurobiology of decision-making dysfunction in stimulant dependent subjects, and to determine if functional imaging could be used as a tool to predict relapse.
