Analyses of the POMS subscales did not reveal any significant main effects for Happiness, Tension, Vigor, or Depression. However, a 2 (Trial) × 2 (Genotype) mixed ANCOVA analysis of the Happiness subscale revealed a significant Genotype × Trial interaction (F(4, 136)=2.51, p =.04). A/A and A/C individuals reported greater happiness than C/C individuals at baseline, a trend that approached significance (t(36)= −1.89, p=0.07). After co-varying this baseline difference, A/A and A/C individuals’ happiness decreased after smoking, while C/C individuals’ happiness increased (see Fig. 2). Analyses of the Tension, Vigor, and Depression subscales did not reveal any significant genotype interactions. Withdrawal severity did not predict changes on any POMS subscales after marijuana.
