Chunk #20 — MATERIALS AND METHODS — Statistical methods — Analysis of the association between rs1051730 genotype and the odds of continued smoking in pregnancy.

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A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy.

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It is possible that any association observed in our study between rs1051730 and smoking cessation in pregnancy would be secondary to the known association with smoking quantity. To test this hypothesis, we repeated the analysis with pre-pregnancy smoking quantity included as a covariate.