Sample-size weighted fixed-effects meta-analysis was performed with METAL94. Within each dataset and ancestry group, summary statistics were filtered to MAF ≥ 1% and imputation information score ≥ 0.6. Meta-analyses were performed within the EA, AA, and LAT ancestry groups. A multi-ancestry meta-analysis was performed as the meta-analysis of the three meta-analyses. Genome-wide significance was declared at P < 5 × 10−8. Heterogeneity between datasets was tested with the Cochran test. Markers with summary statistics in less than 80% of the total effective sample size were removed from meta-analyses. LDSC24 intercept was used to estimate inflation of test statistics related to artifacts rather than genetic signal. The proportion of inflation of test statistics due to the actual polygenic signal (rather than other causes such as population stratification) was estimated as 1 − (LDSC intercept − 1)/(mean observed Chi-square − 1).
