Next, we compared the association analyses results on simulated datasets. We performed single variant tests, as well as simple burden, SKAT and VT tests analyzing rare variants with MAF < 5%. RVTESTS attains a good balance of time and memory usage compared with other tools, e.g. completing the simple burden test took RVTESTS/PSEQ/VAT a 15.7/60.2/374.8 h, and required 1.6/10.0/0.8 GB of RAM (Supplementary Table S3).
