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Chunk #38 — Discussion

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Electroencephalographic Cross-Frequency Coupling as a Sign of Disease Progression in Patients With Mild Cognitive Impairment: A Pilot Study.
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this may have induced some additional noise to the calculations. Due to line noise, we calculated the amplitude of gamma between 30 and 40 Hz, which is a narrow range compared to the previous studies analyzing CFC (Canolty and Knight, 2010). In addition, the gamma band for standard scalp EEG has been suggested to be highly influenced by muscle activity (Whitham et al., 2007, 2008), and this poses some limitations in implementing this technique as a clinical tool. Nevertheless, our findings in this small pilot study with decreased global gamma/theta CFC in patients with pMCI compared to patients with sMCI may be able to guide larger studies.