In contrast to other lipid signaling molecules such as prostaglandins or endocannabinoids, a receptor for EETs has not been identified [40]. Cyclooxygenase generated metabolites of AA such as PGE2 and thromboxane bind to a family of G protein coupled receptors (GPCR) including E and D prostanoid receptors 1–4 and the thromboxane receptor [41, 42]. The endocannabinoids which have similarities with eicosanoids as lipid signal messengers affecting nociception also act on identified GPCR receptors named cannabinoid receptors with subtypes 1 and 2 [43]. Identification of a specific receptor for EETs will certainly be a major step towards understanding the biological roles of these molecules. Currently with the use of recently synthesized EET mimetics [44, 45] and antagonists [46] the search for an epoxyeicosatrienoic acid receptor is underway. However given the diversity of the effects of EETs reported so far it is possible that a number of receptors exist.
