drugs of abuse and receives extensive excitatory afferents from the PFC, amygdala and hippocampus (Carelli, 2002; Volkow et al., 2006). On the other hand, efferent projections from the motor cortex to the dorsal striatum allows this subregion to gate sensorimotor function and have been implicated in the advanced stages of habitual drug seeking (Fasano and Brambilla, 2002; Gerdeman et al., 2003; Philibin et al., 2011).