Chunk #8 — Results

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Tobacco smoking is associated with methylation of genes related to coronary artery disease.

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batch effects, systolic blood pressure, total cholesterol, triglycerides, daily alcohol intake, type 2 diabetes mellitusCurrent-Former: adjusted for age, sex, BMI, Houseman estimates, batch effectsAdjusted model: current-former, adjusted for age, sex, BMI, Houseman estimates, batch effects, systolic blood pressure, total cholesterol, triglycerides, daily alcohol intake, type 2 diabetes mellitusTable 3Association between packyears and cessation time and methylation of significant CpG sitesPackyearsa Cessation timeb CpG siteEstimate (se) p-valueEstimate (se) p-valuecg24908166−0.001 (0.001)0.24−0.003 (0.001)0.02cg12324353−0.003 (0.001)2.3 × 10−3 0.002 (0.001)0.05cg03725309−0.002 (0.002)0.150.004 (0.002)0.02cg00980784−0.003 (0.001)0.01−0.001 (0.001)0.69cg13916835−0.002 (0.002)0.140.002 (0.002)0.24cg09469355−0.003 (0.001)0.04−0.006 (0.001)6.0 × 10−5 cg05603985−0.002 (0.001)0.030.004 (0.001)1.2 × 10−3 cg04324276−0.002 (0.001)0.220.002 (0.001)0.17cg25468516−0.001 (0.001)0.200.003 (0.001)0.06cg22907952−0.003 (0.001)1.8 × 10−3 0.002 (0.001)0.12cg15474579−0.004 (0.001)0.020.005 (0.001)1.5 × 10−3 cg204968960.002 (0.002)0.12−0.003 (0.001)3.9 × 10−3 cg093972460.001 (0.002)0.35−0.001 (0.002)0.38cg264050200.002 (0.001)0.06−0.002 (0.001)0.05cg18236066−0.002 (0.001)0.180.003 (0.001)0.04Bonferroni-corrected threshold 3.3 × 10−3 aIn current smokers, per 10 packyears, adjusted for age, sex, BMI, Houseman estimates, batch effects bIn former smokers, per 10 years of smoking cessation, adjusted for age, sex, BMI, Houseman estimates, batch effects