BXD recombinant inbred mouse data were retrieved and analyses were performed using the WebQTL (www.genenetwork.org) data and analysis suite (Wang et al. 2003). GeneNetwork is an online data repository with integrated computational tools designed to allow users to explore complex genetic networks by integrating data from different sources. The BXD resource (a small subset of the collected data) contains over 2800 measured phenotypes, which were contributed by hundreds of scientists, all linked to genotypes, providing an easily accessible tool to genetically map traits of interest. Phenotypes were selected by searching the BXD phenotype database using the search strings “ethanol AND ataxia” as well as “alcohol AND ataxia,” From the returned list of phenotypes, those that described ataxic response to the administration of ethanol were selected for interval mapping.
