In summary, the present study sought to advance knowledge on GxE effects that are hypothesized to contribute to youths' positive affect. As scant research has investigated whether genetically susceptible individuals flourish in response to supportive environments,31 and no study has investigated this hypothesis with youth, we sought to explicitly examine whether genetically susceptible youth, specifically 5-HTTLPR short-allele carriers, would exhibit both low and high levels of positive affect under the environmental contexts of the lack of positive parenting to supportive parenting, respectively.