Pathway and biological enrichment analyses were performed for each population using the FUMA platform26, with independent significant SNPs identified using the default settings. Positional gene mapping identified genes up to 10 kb from each independent significant SNP. Hypergeometric tests were used to examine the enrichment of prioritized chemical and genetic perturbation gene sets, canonical pathways, and GO biological processes (obtained from MsigDB c2), and GWAS-catalog enrichment (obtained from reported genes from the GWAS-catalog). We report all significantly enriched gene sets based on an FDR-adjusted p value <0.05.
