The 32 confirmed associations included all 19 loci with P < 5×10−8 at stage 1, 12 additional novel loci near RBJ/ADCY3/POMC, QPCTL/GIPR, SLC39A8, TMEM160, FANCL, CADM2, LRP1B, PTBP2, MTIF3/GTF3A, ZNF608, RPL27A/TUB, NUDT3/HMGA1, and one locus (NRXN3) previously associated with waist circumference15 (Table 1, Supplementary Table 1, Supplementary Fig. 1 and 2). In all, our study increased the number of loci robustly associated with BMI from 10 to 32. Four of the 22 new loci were previously associated with body weight10 or waist circumference14,15, whereas 18 loci had not previously associated with any obesity-related trait in the general population. Whilst we confirmed all loci previously established by large-scale GWA studies for BMI6–10 and waist circumference14,15, four loci identified by GWA studies for early-onset or adult morbid obesity16,17 [at NPC1 (rs1805081; P = 0.0025), MAF (rs1424233; P = 0.25), PTER (rs10508503; P = 0.64), and TNKS/MSRA (rs473034; P = 0.23)] showed limited or no evidence of association with BMI in our study.
