SNPs define a haplotype association16. The risk alleles of these two SNPs are negatively correlated (r = –0.53 and –0.59 in the ARIC and QIMR cohorts, respectively); therefore, the secondary SNP (rs10757282; PM = 3.1 × 10–4) was masked by the primary SNP (rs10965250; PM = 1.0 × 10–10) in single-SNP analyses. When they were fitted jointly, their effects, as well as statistical significance, were substantially increased compared to what was obtained in single-SNP analyses.
