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Chunk #1 — Methods summary

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Common variants on chromosome 6p22.1 are associated with schizophrenia.
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For MGS, association of single SNPs to schizophrenia was tested by logistic regression (trend test) using PLINK10, separately for European-ancestry, African American and combined datasets, correcting for principal component scores that reflected geographical gradients or that differed between cases and controls, and for sex for chromosome X and pseudoautosomal SNPs. Genotypic data were imputed for 192 regions surrounding the best findings, and for additional regions selected for meta-analysis.11 Detailed results are available in Supplementary Datafiles 1 and 2, and complete results from dbGAP (www.ncbi.nlm.nih.gov/sites/entrez?db=gap).