Our understanding of molecular events and prognostic markers in CLL was significantly improved by using molecular genetic approaches such as PCR, fluorescence in situ hybridization and microarray analysis. Genomic aberrations were detected in over 80% of CLL cases. These common chromosomal abnormalities include 13q, 11q, 17p and 7q deletions, and trisomy 12 [7]. The 13q14 deletion represents the most common CLL aberration reported in ~50% of all cases (mostly in indolent CLL), on the other hand, ~10–20% of CLL cases do not show chromosomal aberrations [7].
