It is notable that PWSI had little impact on the behavior of the fGluN1 control mice, except partial impairment of PPI (Figure 2E). PWSI was also unable to induce a robust oxidative stress response, measured by DHE (Figure 1), anti-8-OH-dG or 4-HNE staining (Figure 3). These signs of murine resilience to PWSI stress, as recently reported in wild-type mice (52), appear to be in contrast to the recent reports in rats (4,53); however, underlying mechanisms explaining species’ differences are unclear since few such studies have been published with mice (54).
