NAFLD are a spectrum of diseases presenting a major public health concern that is strongly linked with obesity. Most accumulated hepatic fatty acids in NAFLD come from increased non-esterified FFA in the fasting state.17 Thus, it is essential to define the mechanisms by which the liver adapts to this influx. FFA processing largely involves the fatty acid oxidative pathway, coupled to ketogenesis allowing the liver to use lipids,31 which is critical during fasting and requires transcriptional regulation of rate-limiting enzymes.32
