Chunk #60 — Methods — MTAG between PAU and drinks per week.

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Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits.

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Multiple trait analysis between PAU and drinks per week (DrnkWk) from GSCAN was performed on summary statistics with multi-trait analysis of GWAS (MTAG) v1.0.7 [10]. The summary data of DrnkWk were generated from 537,352 subjects, excluding the 23andMe samples that were not available to us for inclusion. We analyzed variants with a minimum effective sample size of 80,603 (15%) in DrnkWk and a minimum effective sample size of 45,118 (15%) in PAU, which left 10,613,246 overlapping variants.