Chunk #36 — Materials and methods — Statistical analysis — Two-by-two tables

Source

Are drug targets with genetic support twice as likely to be approved? Revised estimates of the impact of genetic support for drug mechanisms on the probability of drug approval.

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yes

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Let D be a vector of gene target-indication-phase triplets with elements (gi, ti, hi), i = 1, …, n. Hi ∈ {0, …, 4} is an ordered categorical variable giving the latest phase each gene target-indication pair has achieved (0 = Preclinical, 1 = Phase I, 2 = Phase II, 3 = Phase III, and 4 = US/EU Approved).