[61]. In the current study the non-synonymous SNPs defining CYP2B6*4, CYP2B6*9, as well as CYP2B6*5 (rs3211371 (R487C)) did not show genome-wide significant results, but were in high LD with the top-SNP in CYP2B6 (rs7260329) (S9 Fig). Further, rs7260329 shows modest LD with our independent SNPs rs56113850 (D’ = 0.40), esv2663194 (D’ = 0.65), and rs12461964 (D’ = 0.43), but not with rs113288603 (D’ = 0.04); thus, it is unclear whether the detected association simply reflects LD with the independent variants residing in CYP2A6.
