In summary, recent findings indicate the importance of considering potential racial/ethnic and gender heterogeneity when examining the relation of childhood IPV and SUDs. However, it remains unknown if the relation of childhood trauma and SUD differ by race/ethnicity and/or gender. The current study aims to fill this gap by utilizing data from the National Epidemiologic Survey of Alcohol-Related Conditions-III (NESARC-III), a large nationally representative sample of adults in the USA, to examine the associations of the most commonly occurring, and co-occurring, DSM-5 SUD (AUD, CUD, TUD) with three commonly assessed forms of childhood IPV: physical and sexual abuse, and witnessing parental violence. Toward the aim of teasing apart the specific contribution of childhood IPV to AUD, CUD, and TUD, we also examine the role of parental alcohol and drug use problems, as well as commonly co-occurring substance use and psychiatric disorders. We hypothesize that racial/ethnic and gender differences in rates of exposure to childhood IPV, and in rates of SUD, as well as co-occurring factors such as parental history of substance use problems or participant’s mental health problems, may contribute to differences in the associations of childhood IPV and adult SUD.