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Chunk #26 — Method — Statistical power

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A genome-wide association study of Cloninger's temperament scales: implications for the evolutionary genetics of personality.
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Association analysis was conducted on 1000 data sets generated by the simulation procedure. The empirical power is estimated as that proportion of the 1000 association analyses in which a genome-wide significant association (α = 7.2*10−8) was detected. Results indicated that our sample provides 91.5% power to detect SNPs that explain 1% of the variance in the personality traits, and 26.2% power to detect SNPs that explain 0.5%.