as DHFRL1, MTR and FPGS, possibly related to the alterations in folate and homocysteine observed in AD patients [34], [35], [36] (Table 2, S2, Fig. S4). Figure 4 includes the relationship between NdStress and BioAge, which moderately correlated in AD samples (ρ = 0.53, p<1E–13). At the same time, NdStress and chronological age correlated negatively (ρ = −0.14, p = 0.05). This biomarker score explained 22% of variance in differentially expressed genes and demonstrated AUROC of 0.75 in separating AD and normal samples. See Table 1 for other biomarker characteristics.
