Chunk #20 — Results — Searches for genome wide significance in each European-American sample

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Genomic regions identified by overlapping clusters of nominally-positive SNPs from genome-wide studies of alcohol and illegal substance dependence.

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We identified case vs control p values for t test results from NIDA/MNB samples and for χ2 results from dbGAP samples from unrelated individuals. Permutation testing for the dbGAP European-American samples revealed p<0.0003 (3,000 trials) for the number of SNPs with nominal case vs control p values<0.05. However, virtually none of these p values reached the 10−8 level deemed necessary for genome wide significance.