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Chunk #62 — Online Methods — Functionally informed fine-mapping of 49 complex traits in the UK Biobank

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Functionally informed fine-mapping and polygenic localization of complex trait heritability.
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To compare our fine-mapping results with those of refs.7,12, we restricted the comparison to SNPs that were not excluded from our fine-mapping procedure (SNPs having MAF≥0.001 in the UK Biobank N=337K dataset, INFO score≥0.6, distance <1Mb away from the closest locus center, and not residing in one of the excluded long-range LD regions). When the same SNP had multiple reported PIPs in ref. 12, we used the entry with the larger PIP. We caution that the comparison with ref. 12 is not a replication analysis because the datasets of ref. 12 and of PolyFun + SuSiE are correlated.