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Chunk #3 — Results — Design rationale and initial imaging phase

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Multimodal population brain imaging in the UK Biobank prospective epidemiological study.
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We present results from the first data release (biobank.ctsu.ox.ac.uk/crystal/label.cgi?id=100), which includes outputs from the processing pipeline for 5285 subjects scanned in 2014-2015. As determined by the processing pipeline, 98% of participants’ datasets resulted in a usable T1, which is crucial for deriving usable information from the other modalities. Of these, data for the other brain imaging modalities were suitable for processing in the following percentages of subjects: T2=97%, swMRI=93%, dMRI=95%, tfMRI=92%, rfMRI=95%. All modalities were acquired and usable in 89% of subjects. Results from this data release are illustrated in Figs 1-4, including a multimodal atlas (separate population-average images for each of the modalities, all aligned to each other), available for download and online browsing (www.fmrib.ox.ac.uk/ukbiobank). Below, we present the following analyses: voxel-by-voxel analyses of age effects; pair-wise correlations of brain IDPs with other subject measures; multivariate analysis identifying dominant population patterns linking brain IDPs to other measured parameters; and an exemplar hypothesis-led study of aging, body mass index and smoking.