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Chunk #19 — DISCUSSION

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Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains.
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We report a lower h2SNP for ADHD (h2SNP = 0.14) than estimated previously (h2SNP = 0.22). This is driven by a lower h2SNP in the PGC and deCODE cohorts compared to iPSYCH. Different ascertainment and diagnostic strategies and designs among PGC cohorts could decrease the h2SNP, while a lower effective sample size43 in Iceland, and thus fewer recent variants, might bias h2SNP downwards in the deCODE cohort44.