Statistical analyses were performed by using SPSS for the Macintosh (SPSS, Inc., Chicago, IL). Brain regions were assessed independently. Data analyses were performed on ERO energy and PLI for the ROIs in response to standard, rare and noise tones. Group (B6 vs D2 or HAP-1 vs. LAP-1 vs. HS/Ibg) was assessed as a between subject variable. Tone (standard, rare and noise) was assessed as within subject repeated measures. To assess between strain differences, two-way repeated measures ANOVA were used. For all repeated measures analyses, Greenhouse-Geisser corrected P-values were reported to account for violations of sphericity. When appropriate, post hoc analysis of two-way repeated measures ANOVA (Group × Tone) utilized one-way ANOVA to assess strain differences. Post hoc analysis of two-way repeated measures ANOVA (Tone) utilized pairwise comparisons. Post hoc analysis of one-way ANOVA (Group) utilized the Least Square Difference (LSD) test. For these analyses, P-value was set at P < 0.05 to determine the levels of statistical significance. Independent one-way ANOVA were used to assess baseline differences in ERO energy between strains. To correct for multiple comparisons of ROIs, P-value was set at P < 0.01 to determine the levels of statistical significance.
