Yet, there are still other voxel-based morphometry studies demonstrating no SG differences in global or regional brain volume loss, including insula volume, in women and men with AUD compared to same-sex healthy controls (Demirakca et al., 2011; Senatorov et al., 2015); although, there was evidence of widespread brain volume loss overall in individuals with AUD or who were undergoing alcohol withdrawal compared to healthy controls, consistent with the larger literature of brain volume loss with chronic, excessive alcohol consumption.
