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Chunk #78 — Online Methods — The EZ model, and applying mash to Z scores.

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Flexible statistical methods for estimating and testing effects in genomic studies with multiple conditions.
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Effects” (EE) model23. An alternative is to allow the effects to scale with standard error, so that effects with larger standard error tend to be larger, Sj−1bj | π,U,Vj ~ g, where g is shorthand for the mixture of MVNs (eq. 3). We refer to this as the “Exchangeable Z” (EZ) model because the left of this equation is the vector of Z scores for effect j.