We investigated whether detectable clonal mosaicism predisposes to incident hematological cancer after DNA sampling by using three GENEVA studies, which included cohorts with cancer diagnosis records both before and after DNA sampling. From the following studies, we analyzed 8,562 subjects who had DNA derived from blood and no record of hematological cancer prior to DNA sampling: (1) Glaucoma study, with subjects from the Nurses Health Study (NHS, N=363) and Health Professionals Follow-up Study (HPFS, N=285), (2) Lung Cancer study, with subjects from the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial (PLCO, N= 1600) and (3) Prostate Cancer study, with subjects from the Multiethnic Cohort (MEC, N=6314). Among the 8,562 subjects analyzed for incident hematological cancer, 8,323 were non-mosaics with no events, 90 were non-mosaics with events, 134 were mosaics with no events, and 15 were mosaics with events (where ‘event’ is a hematological cancer diagnosis).
