The allele frequencies in the NYS were similar to those reported in the literature (Table 5). There was evidence for differences in SNP minor allele frequencies among ethnic groups, to the extent that the minor allele was different in Caucasians and African Americans. This dramatic difference in allele frequencies was seen in rs7004381, rs4950, rs13280604, rs35389610, rs892413, and rs1072003 (Chi-Square, all p<0.01). Only rs4953 showed no evidence of differences between allele frequencies in African Americans versus Caucasians (p = 0.30). The representation of other ethnic groups, such as Hispanics, is too small in this sample to obtain accurate allele frequencies and test for frequency differences. One SNP, rs35389610 was too rare to be informative in a sample of this size (MAF = 0.006) and was excluded from all genetic association analyses.
