Chunk #74 — Methods/Design — Statistical models for primary analysis 1 — Arm A analysis — Analysis model 1A1

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Protocol for a collaborative meta-analysis of 5-HTTLPR, stress, and depression.

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In this analysis, model fit using a likelihood ratio test is compared with and without the interaction term to evaluate whether there is statistically significant evidence for the interaction. Our primary analysis will use an additive coding for genotype based on the number of S alleles carried and lifetime diagnosis of depression.