We applied stratified LD score regression to 17 diseases and quantitative traits: height, BMI, age at menarche, LDL levels, HDL levels, triglyceride levels, coronary artery disease, type 2 diabetes, fasting glucose levels, schizophrenia, bipolar disorder, anorexia, educational attainment, smoking behavior, rheumatoid arthritis, Crohn’s disease, and ulcerative colitis [18, 24–36] (Supplementary Table 3, URLS). This includes all traits with publicly available summary statistics with sufficient sample size, SNP-heritability, and polygenicity measured by the z-score of total SNP-heritability; specifically, we restricted to traits for which the z-score of total SNP-heritability was at least 7 (Supplementary Note). We removed the MHC region from all analyses, due to its unusual LD and genetic architecture.
