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Chunk #37 — Developmental functional connectivity studies

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Functional brain imaging across development.
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and 57 years [30]. The progressive age-associated deactivation of medial frontal DMN regions could also potentially account for the shift of medial to lateral frontal activation observed in some developmental studies. Functional connectivity studies furthermore show that children (8–12 years) have more short-distance connections while adults develop more long-distance connections, for example, between DLPFC and parietal regions or between frontal and cerebellar regions for cognitive control networks or between medial frontal and posterior cingulate and parietal regions for the DMN, with adolescents (13–17 years) showing intermediate patterns [36, 37, 80, 81]. This suggests progressive functional development of the DMN as well as of cognitive control networks between childhood and adulthood through simultaneous progressive integration (increased distributed long-distance connections) and segregation (diminished local short-distance connections), both of which are likely related to progressive myelination and synaptic pruning, respectively [82, 83]. Progressive strength of the functional inter-regional connectivity of both intrinsic cognitive control networks and task-negative DMN is likely associated with progressive cognitive maturation [84]. An impactful recent study using multivariate pattern recognition analysis on brain development using resting state fMRI data on 238 subjects between 7 and 30 years showed that maturation was predicted by a non-linear pattern of increasingly longer