(Lewohl et al., 2011). In the nucleus accumbens, down-regulation of the mir-34b/c family was observed (Mamdani et al., 2015). Dysregulation of miR-34b/c triggered downstream transcriptome alterations underlying mitochondrial dysfunction and oxidative stress in Parkinson’s disease, which ultimately compromised cell viability (Minones-Moyano et al., 2011). The link between certain miRNA targets and genes implicated in neurodegeneration suggests a neurotoxic effect on cell function in AUD and other diseases.
