important region of the genome, SNPs are only one type of genetic variation, and important non-SNP genetic variation might not have been sufficiently well captured. (c) There was an imbalance in the proportion of males in cases and controls. Although it is unclear whether and how this might bias the results, it may have lead to some degree of bias. (d) Finally, GWAS are predicated upon the crucial assumption that the predominant diagnostic criteria are valid with respect to the fundamental architecture of the disorder.
