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Chunk #0 — Identification of 97 genome-wide significant loci

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Genetic studies of body mass index yield new insights for obesity biology.
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This BMI meta-analysis included association results for up to 339,224 individuals from 125 studies, 82 with GWAS results (n = 236,231) and 43 with results from Metabochip (n = 103,047; Extended Data Table 1 and Supplementary Tables 1–3). After regression on age and sex and inverse normal transformation of the residuals, we carried out association analyses with genotypes or imputed genotype dosages. GWAS were meta-analysed together, as were Metabochip studies, followed by a combined GWAS plus Metabochip meta-analysis. In total, we analysed data from 322,154 individuals of European descent and 17,072 individuals of non-European descent (Extended Data Fig. 1).