Extended description of the cohorts and phenotypes is supplied in the Supplementary text and Supplementary Tables 1–9. Cohorts with assessment of AGG in genotyped children and adolescents took part in the meta-analysis. AGG was assessed on continuous scales, with higher scores indicating higher levels of AGG. Within cohort, samples were stratified by (1) rater, (2) instrument, and (3) age, maintaining at least 450 observations in each stratum. We ran a univariate GWAS for each stratum within each cohort (Supplementary Table 8). GWASs were run by local analysts following a standard operation protocol (see URLs) after which the summary statistics were uploaded to a central location for the meta-analysis. To account for dependence within cohort in the meta-analysis (see Supplementary text), each cohort supplied the phenotypic covariance matrix between the AGG measures (Supplementary Table 10) and the degree of sample overlap (Supplementary Table 11) between the different strata. Supplementary Fig. 1 shows the distribution of phenotypic correlations across all AGG measures. We assumed no sample overlap across cohorts, and phenotypic correlations among cohorts were set to zero and omitted from Supplementary
