The sample included 1864 adolescents and young adults (903 males and 961 females) between 12 to 25 years of age (see Table 1) and was derived from the prospective study of the Collaborative Study on the Genetics of Alcoholism (COGA) (Begleiter et al., 1995; Edenberg et al., 2005). The prospective study began in 2004, focusing on participants who were relatives (e.g., offspring) of the high-risk and comparison (comparison) families ascertained in previous phases of COGA. Participants are reassessed every two years with clinical, behavioral and neurophysiological assessments. Data from six collection sites have been included in this study: SUNY Downstate Medical Center at Brooklyn, New York; University of Connecticut Health Science Center; Washington University School of Medicine in St. Louis; University of California at San Diego; University of Iowa, and Indiana University School of Medicine. Recruitment and assessment procedures have been described elsewhere (Begleiter et al., 1995; Reich et al., 1998; Foroud et al., 2000; Nurnberger et al., 2004), and are also available at this website: https://zork5.wustl.edu/coganew/data/instruments.html. The experimental protocols were approved by each site’s institutional review board, and informed consent was obtained from all participants.
