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Chunk #36 — DISCUSSION

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Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells.
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cones and showing limited integration at 3 months post grafting (data not shown). Those data are in contrast to our in vitro co-culture work where rapid functional integration and phenotypic maturation was readily achieved. In sum, this study provides a framework for the generation of distinct ventral prosencephalic neuron types that can be used to study various aspects of development and serves as a powerful in vitro platform to study dysfunction of specific neuron types implicated in a myriad of neuropsychiatric diseases.