A disconnection hypothesis was proposed in which the pathophysiology of schizophrenia is expressed at the level of modulation of associative changes in synaptic efficacy, specifically modulation of plasticity in those brain systems [67-71]. The theoretical mechanism of dysfunction in connectivity in the higher order cognitive task may be associated with disturbance of the local inhibitory local cortical circuit [72] and the subcortical generation system, that is, dysfunction of the thalamo-cortical tract [73]. Although the mechanisms involved in large scale integration are still unknown, the formation of dynamic links may be mediated by synchrony over multiple frequency bands [74]. The “communication-through-coherence” hypothesis showed that oscillations in neural activity are fundamental for modulat-ing, filtering, and routing information in the nervous system [42, 43]. The neuronal communication is mechanically subserved by neuronal coherence, and activated neuronal groups oscillate and undergo rhythmic excitability fluctuations that that produce temporal windows for communication [42, 43]. The alpha oscillations exercise a strong inhibitory influence on both spike timing and firing rate, and thus the pulsed inhibition by alpha oscillation plays an important role in the extended sensorimotor
